![]() Human Diseases > Cancers: Specific types > Thyroid cancer.Human Diseases > Cancers: Specific types > Endometrial cancer.Human Diseases > Cancers: Overview > Pathways in cancer.Human Diseases > Infectious diseases: Bacterial > Pathogenic Escherichia coli infection.Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs).Environmental Information Processing > Signal transduction > Hippo signaling pathway.Environmental Information Processing > Signal transduction > Apelin signaling pathway.Environmental Information Processing > Signal transduction > Rap1 signaling pathway.Cellular Processes > Cellular community - eukaryotes > Adherens junction.The formation of the complex between InlA and cadherin-1 is calcium-dependent. (Microbial infection) Interacts with L.monocytogenes InlA. Forms a ternary complex composed of ADAM10, CADH1 and EPHA4 within the complex, CADH1 is cleaved by ADAM10 which disrupts adherens junctions (By similarity). Interacts with DDR1 this stabilizes CDH1 at the cell surface and inhibits its internalization. Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions (CAJs). Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1 (By similarity). The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex (By similarity). ![]() Interacts with the TRPV4 and CTNNB1 complex (By similarity). Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1, beta-catenin/CTNNB1 or gamma-catenin/JUP, and potentially alpha-catenin/CTNNA1 the complex is located to adherens junctions. Thr-285 and Thr-509 are O-mannosylated by TMTC2 or TMTC4 but not TMTC1 or TMTC3. O-manosylated by TMTC1, TMTC2, TMTC3 or TMTC4. Ubiquitinated by CBLL1/HAKAI, requires prior phosphorylation at Tyr-754. Ubiquitinated by a SCF complex containing SKP2, which requires prior phosphorylation by CK1/CSNK1A1. Addition of bisecting N-acetylglucosamine by MGAT3 modulates its cell membrane location. N-glycosylation at Asn-637 is essential for expression, folding and trafficking. During development of the cochlear organ of Corti, cleavage by ADAM10 at adherens junctions promotes pillar cell separation (By similarity). The gamma-secretase-mediated cleavage promotes disassembly of adherens junctions. Cleavage by caspase-3 releases the cytoplasmic tail resulting in disintegration of the actin microfilament system. The residual membrane-tethered cleavage product is rapidly degraded via an intracellular proteolytic pathway. Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion and the subsequent release of beta-catenin into the cytoplasm. During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase (ADAM10), PS1/gamma-secretase and caspase-3.
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